Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non‐Remission in Patients With Major Depressive Disorder

Shudong Zhang, Zhifang Zhang, Xiaoya Li, Jingjing Zhou, Ruinan Li, Rui Liu, Yun Wang, Xiongying Chen, Yuan Feng, Jian Cui, Ling Zhang, Yuan Zhou, Gang Wang · 2026

Read Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non‐Remission in Patients With Major Depressive Disorder by Shudong Zhang, Zhifang Zhang, Xiaoya Li, Jingjing Zhou, Ruinan Li, Rui Liu, Yun Wang, Xiongying Chen, Yuan Feng, Jian Cui, Ling Zhang, Yuan Zhou, Gang Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13254815.txt.

Description

Shudong Zhang and a large team track brain links during depression treatment in a 2026 study. Forty-eight patients with major depressive disorder had resting-state brain scans over an eight-week treatment course, and 44 healthy controls had a baseline scan. Patients were split by whether their symptoms remitted.

One link, between a part of the amygdala and a motor area, started low in the remission group and high in the non-remission group versus controls. During treatment, that link moved toward normal at two and eight weeks in the remission path. Baseline links tied to treatment response, though some results faded after strict checks.

Catalog record

CREATORShudong Zhang, Zhifang Zhang, Xiaoya Li, Jingjing Zhou, Ruinan Li, Rui Liu, Yun Wang, Xiongying Chen, Yuan Feng, Jian Cui, Ling Zhang, Yuan Zhou, Gang Wang
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE51056
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13254815

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