Multi-omics analysis identifies CKLF as a promoter for HCC progression by regulating the AKT, ERK pathways, and infiltrating immune cells
Lei Peng, Jingjing Li, Ji Yuan, Shuangshuang Ma, Lei Jin, Guizhou Zou, Lei Tang · 2026
Read Multi-omics analysis identifies CKLF as a promoter for HCC progression by regulating the AKT, ERK pathways, and infiltrating immune cells by Lei Peng, Jingjing Li, Ji Yuan, Shuangshuang Ma, Lei Jin, Guizhou Zou, Lei Tang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13254726.txt.
Description
Peng and colleagues combined bulk, single-cell, and spatial data to position the chemokine-like factor CKLF as a driver of liver cancer growth. CKLF was more abundant in hepatocellular carcinoma tissue than in normal liver, and high levels tracked with later stage, distinct molecular subtypes, and shorter survival. The factor appeared in tumor cells and in infiltrating immune cells alike.
Laboratory tests supported a causal role: silencing CKLF slowed proliferation, movement, and colony growth in liver cancer cell models. Forcing the Ras pathway on partly reversed those effects, placing CKLF upstream of AKT and ERK signaling. The authors propose CKLF as both a prognostic marker and a drug target.
Catalog record
| CREATOR | Lei Peng, Jingjing Li, Ji Yuan, Shuangshuang Ma, Lei Jin, Guizhou Zou, Lei Tang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |