Super-enhancer-driven ITGB2-AS1 promotes ovarian cancer progression by binding to IQGAP1
Yuhan Wang, Peiling Li · 2026
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Description
Yuhan Wang and Peiling Li investigate a long non-coding RNA that accelerates ovarian cancer in a 2026 study. The molecule, ITGB2-AS1, does not code for a protein but regulates other genes, and it was found abnormally expressed in ovarian tumors. Ovarian cancer spreads aggressively and its five-year survival remains low, so its molecular drivers are prized targets.
The authors show the RNA's production is switched on by a super-enhancer, an unusually powerful cluster of gene-activating elements that cancers often hijack for growth genes. Inside the cell, ITGB2-AS1 physically binds a scaffold protein called IQGAP1. That binding switches on the Wnt and beta-catenin signaling pathway, a classic engine of cell growth and movement. The authors present the super-enhancer, the RNA, and its protein partner as connected points where future drugs might intervene.
Catalog record
| CREATOR | Yuhan Wang, Peiling Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |