AMPK in charge: aerobic glycolysis programs unilocularity in adipocytes
D.J. Kast · 2026
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Description
Kast comments on new work showing how an energy-sensing enzyme shapes fat cell structure in a 2026 paper. Healthy white fat cells hold one large lipid droplet, which stores fat safely. Lab-grown fat cells usually fail to form that single droplet.
The discussed study found a metabolic program, driven by aerobic glycolysis under the enzyme AMPK, that produces the single-droplet form in culture. Kast explains why droplet size matters: surface proteins govern storage, release, and contact with other cell parts. Two-dimensional cultures also switch on programs absent in real tissue. Better models should sharpen obesity research. The piece is a commentary on another group's experiments. It frames the advance for fat biology.
Catalog record
| CREATOR | D.J. Kast |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |