Hijacking the bone niche: mechanistic insights into bone metastasis in breast cancer
Jiadi Wu, Min Deng, Feng Ye, Wei Deng, Zichao Wu, Xinhao Zheng, Cailu Song, Yutian Zou, Hailin Tang · 2026
Read Hijacking the bone niche: mechanistic insights into bone metastasis in breast cancer by Jiadi Wu, Min Deng, Feng Ye, Wei Deng, Zichao Wu, Xinhao Zheng, Cailu Song, Yutian Zou, Hailin Tang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13254371.txt.
Description
Jiadi Wu and colleagues review how breast cancer takes over bone in a 2026 paper. Bone is the most common spread site in breast cancer, at about 70 percent of metastatic cases. Before cancer cells arrive, the primary tumor sends out factors that prepare a supportive niche in bone.
Once there, tumor cells release signals that stir bone-eating cells and upset bone-building cells. Breaking down bone frees growth factors that feed the tumor, forming a vicious cycle. The cells also suppress local immunity and grow new vessels. The review covers cell talk in both stages and new treatment ideas beyond standard care.
Catalog record
| CREATOR | Jiadi Wu, Min Deng, Feng Ye, Wei Deng, Zichao Wu, Xinhao Zheng, Cailu Song, Yutian Zou, Hailin Tang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72967 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |