Histaminylation alters collagen matrix mechanics and attenuates cardiac fibrosis post-myocardial infarction via mechanotransduction signaling axis
Jianfu Zhu, Dili Sun, Gaofeng Zeng, Kehan Wu, Xiyang Yang, Xiaowei Zhu, Diyaerjiang Aierken, Suling Ding, Xiangfei Wang, Junbo Ge, Xiangdong Yang · 2026
Read Histaminylation alters collagen matrix mechanics and attenuates cardiac fibrosis post-myocardial infarction via mechanotransduction signaling axis by Jianfu Zhu, Dili Sun, Gaofeng Zeng, Kehan Wu, Xiyang Yang, Xiaowei Zhu, Diyaerjiang Aierken, Suling Ding, Xiangfei Wang, Junbo Ge, Xiangdong Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13254370.txt.
Description
Jianfu Zhu and a large team study a chemical tweak to heart scar tissue in a 2026 paper. After a heart attack, collagen in the scar can stiffen the heart. The team found histaminylation, a histamine-based modification made by an enzyme called TGM2, in mouse heart collagen seven days after infarction.
Mice unable to make histamine had more crosslinks and stiffer scars. In lab tests, histaminylated collagen formed fewer crosslinks, stayed softer, and slowed scar-forming cell change. A gel releasing histamine, placed at the injury, restored the modification and reduced heart dysfunction in those mice.
Catalog record
| CREATOR | Jianfu Zhu, Dili Sun, Gaofeng Zeng, Kehan Wu, Xiyang Yang, Xiaowei Zhu, Diyaerjiang Aierken, Suling Ding, Xiangfei Wang, Junbo Ge, Xiangdong Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64180 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |