The degenerome—a novel streamline-wise approach for white matter integrity in neurodegeneration
Jonas A Hosp, Marco Reisert, Nils Schröter, Elias Kellner, Hansjörg Mast, Michel Rijntjes, Sabine Hellwig, Lars Frings, Heinz Wiendl, Horst Urbach, Alexander Rau · 2026
Read The degenerome—a novel streamline-wise approach for white matter integrity in neurodegeneration by Jonas A Hosp, Marco Reisert, Nils Schröter, Elias Kellner, Hansjörg Mast, Michel Rijntjes, Sabine Hellwig, Lars Frings, Heinz Wiendl, Horst Urbach, Alexander Rau (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13254335.txt.
Description
Jonas Hosp and a large team introduce a brain mapping method in a 2026 study. Neurodegenerative diseases harm both gray matter and the long white-matter paths that link brain areas. Their streamline-wise method, yielding what they call a degenerome, maps axon loss along about 20,000 fiber paths from diffusion MRI scans.
Groups included Alzheimer's disease with 81 patients, Parkinson's with 177, and two rarer diseases, plus 26 healthy controls. Each disease showed a distinct fiber pattern matching known anatomy, such as limbic paths in Alzheimer's. The patterns separated the diseases and allowed single-patient views.
Catalog record
| CREATOR | Jonas A Hosp, Marco Reisert, Nils Schröter, Elias Kellner, Hansjörg Mast, Michel Rijntjes, Sabine Hellwig, Lars Frings, Heinz Wiendl, Horst Urbach, Alexander Rau |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39671 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |