Thermodynamic coupling between cold and heat activations of TRPV2
Guangyu Wang · 2026
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Description
Guangyu Wang models how a heat-sensing channel opens in a 2026 computational study. TRPV2 is a channel protein that responds to high heat, with a sharp threshold above body temperature. Using cryo-EM structures of rat TRPV2 and a sensitive thermoring model, Wang mapped weak links on the protein surface.
A stable pre-open state showed at least three weakest bridges acting as primary heat sensors. Chemical changes away from those sensors opened the channel but with lower cold sensitivity. Full opening needed broken links between subunits near the sensors. The author says a heat capacity mechanism can explain the sharp response.
Catalog record
| CREATOR | Guangyu Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56522 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |