Baseline state for pulmonary vasculature with pulmonary arterial hypertension: effect of geometric remodeling and metabolic shift
Haritha N Mullagura, Hamidreza Gharahi, C Alberto Figueroa, Seungik Baek · 2026
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Description
Haritha Mullagura and co-authors build a baseline model of diseased lung arteries in a 2026 study. Pulmonary arterial hypertension means lasting high pressure in lung arteries, driven by wall reshaping and energy shifts. Their framework combines vessel shape, wall makeup, and blood flow in model artery trees.
Compared with healthy vessels, model PAH arteries were far stiffer, rising from about 7 to 10 kilopascals to 300 to 800. Walls grew thick while outer width stayed fixed, narrowing the open channel. Energy cost per length more than doubled, so the authors suggest vessels adapt by shifting where energy is spent.
Catalog record
| CREATOR | Haritha N Mullagura, Hamidreza Gharahi, C Alberto Figueroa, Seungik Baek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59000 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |