DGAT1 regulates keratinocyte proliferation through the modulation of retinoid homeostasis
Kamila Kwiecień, Natalia Bryniarska-Kubiak, Agnieszka Morytko, Alicja Uchańska, Maciej Pastuszczak, Marcin Migaczewski, Joanna Cichy, Patrycja Kwiecińska · 2026
Read DGAT1 regulates keratinocyte proliferation through the modulation of retinoid homeostasis by Kamila Kwiecień, Natalia Bryniarska-Kubiak, Agnieszka Morytko, Alicja Uchańska, Maciej Pastuszczak, Marcin Migaczewski, Joanna Cichy, Patrycja Kwiecińska (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13253717.txt.
Description
Kamila Kwiecień and colleagues report a 2026 skin study on DGAT1, a protein that handles fats and vitamin A-like compounds called retinoids. Skin cells called keratinocytes form the skin barrier. The team asked what happens to these cells when DGAT1 is missing, in normal skin and in psoriasis, a scaly skin disease.
Without DGAT1, skin cells grew too fast and the barrier failed under normal conditions. Yet in psoriasis-like swelling, losing DGAT1 slowed cell growth instead. The shift ran through retinoic acid signals, which grew stronger without DGAT1. The authors call DGAT1 a context-based regulator, meaning its effect depends on skin state.
Catalog record
| CREATOR | Kamila Kwiecień, Natalia Bryniarska-Kubiak, Agnieszka Morytko, Alicja Uchańska, Maciej Pastuszczak, Marcin Migaczewski, Joanna Cichy, Patrycja Kwiecińska |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42527 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |