Carbonic anhydrase VIII as a regulator of intracellular calcium signaling: mechanistic insights and implications in human disease
Ashok Aspatwar · 2026
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Description
Ashok Aspatwar reviews carbonic anhydrase VIII, called CA VIII, in a 2026 paper on cell signaling. Most proteins in this family help balance acid in the body, but CA VIII lacks a key part and cannot do that job. Yet it is kept across species and is rich in nerve tissue, hinting at a new role.
Evidence cited shows CA VIII binds a channel that releases calcium inside cells, shaping nerve firing and brain growth. Gene faults in families from Iraq and Saudi Arabia link its loss to ataxia, meaning poor balance, and slow brain growth. The author casts CA VIII as a repurposed signal regulator.
Catalog record
| CREATOR | Ashok Aspatwar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30406 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |