Current Understanding of CHIP’s Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature
Kirti Arora, Rishi Chowdhary, Rachel McNulty, Rahul Chowdhary, Wesam Aleyadeh, Megh Patel, Abhay Singh · 2026
Read Current Understanding of CHIP’s Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature by Kirti Arora, Rishi Chowdhary, Rachel McNulty, Rahul Chowdhary, Wesam Aleyadeh, Megh Patel, Abhay Singh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13253656.txt.
Description
Kirti Arora and colleagues published a 2026 review on CHIP, a blood stem cell change linked to aging. In CHIP, stem cells gain gene changes such as DNMT3A, TET2, ASXL1, and JAK2, yet blood counts stay near normal. The review asks how these clones affect gut and liver health.
The authors report that CHIP acts like a body-wide source of swelling and immune stress. In the liver, some gene changes raise IL-6 signals and scar growth, lifting risk of cirrhosis and liver cancer. In bowel disease, clone cells link to worse illness, and in colon cancer they shape how tumors respond to immune drugs.
Catalog record
| CREATOR | Kirti Arora, Rishi Chowdhary, Rachel McNulty, Rahul Chowdhary, Wesam Aleyadeh, Megh Patel, Abhay Singh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30153 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |