Remodeling mechanisms and intervention strategies of the oral mucosal immune barrier
Zun Wang, Yaohua Guo, Yaguang Fan, Xuebing Li, Wang Shen · 2026
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Description
Zun Wang and co-authors review how the mouth's immune barrier is built, remodeled, and repaired in a 2026 article. The oral mucosa is the body's first defense line for everything swallowed or breathed through the mouth. Its protection is layered: a physical sheet of epithelial cells, chemical weapons in saliva, a resident microbial community, and immune cells that mediate fast defense, fine regulation, and memory.
That network stays in balance through constant cross-talk among epithelium, immune cells, and microbes. Local threats such as infection, autoimmune mouth disease, and oral cancer can break it, as can body-wide conditions like diabetes and cancer chemoradiotherapy. A failing barrier then worsens mouth lesions and can feed body-wide inflammation through the oral-systemic axis. The authors survey repair strategies from microbe tuning and immune pathway drugs to biological scaffolds and nanoparticle drug carriers.
Catalog record
| CREATOR | Zun Wang, Yaohua Guo, Yaguang Fan, Xuebing Li, Wang Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |