A mechanistic computational model of the HIF signaling pathway in endothelial cells
Rebeca Hannah de Melo Oliveira, Arvind P Pathak, Aleksander S Popel · 2026
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Description
Rebeca Hannah de Melo Oliveira, Arvind P. Pathak, and Aleksander S. Popel present a validated computer model of oxygen sensing in blood vessel cells in 2026. When oxygen falls, cells switch on the HIF pathway to adapt and survive, a response central to cancer, heart and limb circulation problems, and eye disease.
The new model describes the HIF pathway in endothelial cells, the cells lining blood vessels, with separate behavior for its two main forms. After identifiability checks and calibration, it reproduced independent datasets with correlations between 0.7 and 0.95 and no systematic bias in its errors. Simulations showed dose-dependent HIF stabilization and a gradual handover of control from the fast-acting form, dominant in brief oxygen drops, to the slower form in prolonged shortage. The authors offer the model as a building block for larger simulations of oxygen-starved disease.
Catalog record
| CREATOR | Rebeca Hannah de Melo Oliveira, Arvind P Pathak, Aleksander S Popel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |