From Preservation to Repair: A Systematic Review of Therapeutic Organ Rehabilitation During Normothermic Ex Vivo Machine Perfusion
Syed Sikandar Raza, Caitlin M. Bocks, Spencer G. Amacher, Kristopher B. Deatrick, Yuliya Tipograf, Alvaro Rojas-Peña · 2026
Read From Preservation to Repair: A Systematic Review of Therapeutic Organ Rehabilitation During Normothermic Ex Vivo Machine Perfusion by Syed Sikandar Raza, Caitlin M. Bocks, Spencer G. Amacher, Kristopher B. Deatrick, Yuliya Tipograf, Alvaro Rojas-Peña (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13252994.txt.
Description
Raza and co-authors review attempts to heal donor organs while they sit on warm perfusion machines before transplant. Their 2026 Transplantation Direct systematic review follows the shift from simply preserving organs to actively rehabilitating them. Lung perfusion is the most mature field, with kidney, liver, and heart work emerging behind it.
Of thousands of records screened, twenty-one studies qualified, mostly on kidneys and livers in human or pig organs. Treatments ranged from drugs and cell therapies to fat-removal protocols and circuit tweaks. Nearly all studies improved molecular measures, but barely a third improved actual organ function, and few checked results after transplant. The authors want standard reporting and transplant-linked testing to turn rejected organs into usable grafts.
Catalog record
| CREATOR | Syed Sikandar Raza, Caitlin M. Bocks, Spencer G. Amacher, Kristopher B. Deatrick, Yuliya Tipograf, Alvaro Rojas-Peña |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |