Lactate regulates osteoclastogenesis via H3K18la in osteoarthritis
Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu · 2026
Read Lactate regulates osteoclastogenesis via H3K18la in osteoarthritis by Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13252938.txt.
Description
Fan and co-authors link lactate, a sugar-burning byproduct, to bone-eating cell growth in osteoarthritis. Their 2026 International Journal of Molecular Medicine study uses a mouse model made by cutting a knee ligament, plus cell experiments. The team tracked a chemical tag that lactate leaves on histone proteins inside bone-resorbing osteoclasts.
The tag, called H3K18 lactylation, ran high in arthritic joint osteoclasts alongside lower bone density and worse under-cartilage bone damage. Hormone-driven osteoclast formation raised lactate and the tag together, and a lactate blocker curbed both processes. The tag sat on a gene promoter that drives osteoclast activity and switched it on directly. Injecting the blocker into mouse joints cut osteoclast numbers and eased bone loss, marking the pathway as a treatment target.
Catalog record
| CREATOR | Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |