C-type lectin receptor signaling in schistosomiasis
Santoshi Chaudhary, Parisa Kalantari · 2026
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Description
Santoshi Chaudhary and Parisa Kalantari review how sugar-sensing immune receptors shape schistosomiasis in 2026. The disease, caused by parasitic worms of the genus Schistosoma, affects over 250 million people, and most damage comes from the immune response to worm eggs. Worms coat themselves in distinctive sugars at each life stage, and those sugars are what host C-type lectin receptors read.
The review walks through the main receptors, including the mannose receptor, DC-SIGN, and the Dectins, and the signals each one triggers in immune cells. Depending on which receptor dominates, the response can protect the host, drive the scarring responses behind severe liver disease, or calm inflammation down. These receptors also converse with other sensors such as Toll-like receptors, complicating the picture. The authors highlight open questions about receptor specificity and context. They position these sugar readers as a central control panel for the disease's immune pathology.
Catalog record
| CREATOR | Santoshi Chaudhary, Parisa Kalantari |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |