Long term evaluation of the safety and efficacy of local cooling anesthesia during intravitreal injections: The COOL-2 Trial
Arshad M. Khanani, Samir N. Patel, Charles C. Wykoff, Gun-Ho Kim, Ajay E. Kuriyan · 2026
Read Long term evaluation of the safety and efficacy of local cooling anesthesia during intravitreal injections: The COOL-2 Trial by Arshad M. Khanani, Samir N. Patel, Charles C. Wykoff, Gun-Ho Kim, Ajay E. Kuriyan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13252741.txt.
Description
Arshad Khanani and colleagues report the COOL-2 trial in this 2026 eye study. Injections into the eye are the most common office procedure for retina specialists, yet numbing them usually means a numbing injection of its own, so the team tested freezing instead.
Eighty patients who needed repeated injections were assigned to four cooling settings, mixing two temperatures with different contact times. The winning setting, the colder temperature held for ten seconds, gave the lowest pain scores, clearly beating a fifteen-second hold. Pain also eased slightly with each visit. A mild, short-lived surface scratching appeared in about a third of eyes at one setting. The authors call cooling workable, with care.
Catalog record
| CREATOR | Arshad M. Khanani, Samir N. Patel, Charles C. Wykoff, Gun-Ho Kim, Ajay E. Kuriyan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32745 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |