Asymptomatic and symptomatic cardiac toxicity associated with immune checkpoint inhibitors: insights from a Japanese registry
Yudai Tamura, Yuichi Tamura, Hiroshi Ohtsu, Shiro Nakamori, Kazuaki Maruyama, Nao Muraoka, Masaaki Shoji, Kazuko Tajiri, Hirofumi Tomita, Yoshitaka Iso, Koichiro Sugimura, Hirotsugu Yamada, Koichiro Kinugawa, Ryota Morimoto, Hiroshi Akazawa, Kazumasa Harada, Shintaro Nakano, Kenichi Tsujita, Tadahir · 2026
Read Asymptomatic and symptomatic cardiac toxicity associated with immune checkpoint inhibitors: insights from a Japanese registry by Yudai Tamura, Yuichi Tamura, Hiroshi Ohtsu, Shiro Nakamori, Kazuaki Maruyama, Nao Muraoka, Masaaki Shoji, Kazuko Tajiri, Hirofumi Tomita, Yoshitaka Iso, Koichiro Sugimura, Hirotsugu Yamada, Koichiro Kinugawa, Ryota Morimoto, Hiroshi Akazawa, Kazumasa Harada, Shintaro Nakano, Kenichi Tsujita, Tadahir (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13252459.txt.
Description
Yudai Tamura and co-authors present a 2026 registry study on heart damage from cancer immunotherapy in Japan. Checkpoint inhibitor drugs can inflame the heart, sometimes fatally. Mild cases without symptoms are poorly understood, so the team compared quiet and obvious cases side by side in a national registry.
Ninety patients from 23 hospitals, treated between 2020 and 2022, were classed by guideline grades. Grade 1 meant no symptoms, while grades 2 to 4 meant clear illness. Heart biopsies were taken in 24 patients, including five without symptoms. The average patient was 68, and over three quarters were men. Blood markers, tissue findings, and clinical courses were contrasted between the groups. The data may help doctors judge when a silent case is truly safe.
Catalog record
| CREATOR | Yudai Tamura, Yuichi Tamura, Hiroshi Ohtsu, Shiro Nakamori, Kazuaki Maruyama, Nao Muraoka, Masaaki Shoji, Kazuko Tajiri, Hirofumi Tomita, Yoshitaka Iso, Koichiro Sugimura, Hirotsugu Yamada, Koichiro Kinugawa, Ryota Morimoto, Hiroshi Akazawa, Kazumasa Harada, Shintaro Nakano, Kenichi Tsujita, Tadahir |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |