The Gut-Brain Axis in Comorbidity of Inflammatory Bowel Disease and Anxiety/Depression: Mechanisms, Controversies, and Future Directions
Yuheng Cui, Yangfeng Huang · 2026
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Description
Cui and Huang review how gut and brain talk to each other when bowel inflammation arrives with anxiety or depression. Their 2026 International Journal of General Medicine paper covers Crohn's disease and ulcerative colitis, which often travel with emotional disorders. The gut-brain axis, a two-way network of nerves, immune signals, hormones, and microbes, frames the story.
Four pathways form a self-reinforcing inflammatory cycle, the authors argue, letting gut inflammation disturb mood and stress worsen the gut. Open fights include which direction causality runs, which pathway dominates, and why microbe studies replicate poorly. Single-target anti-inflammatory drugs have performed unevenly in this comorbidity. The authors urge long-term cohorts, omics tools, and multi-target treatments that join gut and psychiatric care.
Catalog record
| CREATOR | Yuheng Cui, Yangfeng Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |