A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging
Chrysovalantou E. Xirouchaki, Esther García-Domínguez, Eamon Coughlan, Meagan J. McGrath, Saveen Giri, Shuwei Liang, Florian Wiede, Anne Bigot, Junichi Sadoshima, Maria C. Gomez-Cabrera, Andrew Philp, Marcus Moberg, William Apró, William Roman, Christina A. Mitchell, Tony Tiganis · 2026
Read A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging by Chrysovalantou E. Xirouchaki, Esther García-Domínguez, Eamon Coughlan, Meagan J. McGrath, Saveen Giri, Shuwei Liang, Florian Wiede, Anne Bigot, Junichi Sadoshima, Maria C. Gomez-Cabrera, Andrew Philp, Marcus Moberg, William Apró, William Roman, Christina A. Mitchell, Tony Tiganis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13251858.txt.
Description
Chrysovalantou Xirouchaki and a large team link a muscle enzyme to ageing in this 2026 study. Exercise switches on a protective stress-response system in muscle, steered by a master protein, and that protection fades with age.
The enzyme NOX4, which makes small amounts of reactive oxygen in working muscle, turned out to feed that protective switch. Its levels fell in aged mice and humans. Mice lacking it in muscle aged badly, with wasting, frailty, weight gain, and liver disease. Restoring the enzyme, or switching the downstream system on with a broccoli-derived compound, brought the exercise-like protection back. The findings frame one way exercise keeps ageing at bay.
Catalog record
| CREATOR | Chrysovalantou E. Xirouchaki, Esther García-Domínguez, Eamon Coughlan, Meagan J. McGrath, Saveen Giri, Shuwei Liang, Florian Wiede, Anne Bigot, Junichi Sadoshima, Maria C. Gomez-Cabrera, Andrew Philp, Marcus Moberg, William Apró, William Roman, Christina A. Mitchell, Tony Tiganis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 111965 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |