Myeloid Cell-Derived Thrombospondin-1 Mediates Anti-Metastatic Effects of Histamine Dihydrochloride in B16 Melanoma
Nuttida Issdisai, Mustafa Kaya, Kristoffer Hellstrand, Hanna Grauers Wiktorin, Anna Martner · 2026
Read Myeloid Cell-Derived Thrombospondin-1 Mediates Anti-Metastatic Effects of Histamine Dihydrochloride in B16 Melanoma by Nuttida Issdisai, Mustafa Kaya, Kristoffer Hellstrand, Hanna Grauers Wiktorin, Anna Martner (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13251772.txt.
Description
Issdisai and colleagues trace how a histamine drug stops melanoma from spreading to the lungs in mice. Their 2026 ImmunoTargets and Therapy study starts from a gene switched on by histamine dihydrochloride in human immune cells. The gene makes thrombospondin-1, a protein found where tumors prepare to seed new growth.
The drug raised thrombospondin-1 output across several myeloid cell types, working through histamine's type-2 receptor and a known signaling chain. Human melanoma data linked higher gene levels with better survival, and tumor tissue showed reduced levels. In mice, the drug raised lung thrombospondin-1 and cut metastasis, but only in animals able to make the protein. The authors name it a key messenger of the drug's anti-spread effect.
Catalog record
| CREATOR | Nuttida Issdisai, Mustafa Kaya, Kristoffer Hellstrand, Hanna Grauers Wiktorin, Anna Martner |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |