Metformin improves cardiac stress tolerance and mitochondrial function during early aging
Qun Chen, Jeremy Thompson, Ying Hu, Edward J Lesnefsky · 2026
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Description
Qun Chen and three co-authors test a diabetes drug as a heart shield for aging mice in a 2026 study. Hearts lose stress tolerance with age, and the damage starts quietly in middle age. A protein-folding strain inside cells, called ER stress, climbs as hearts age and peaks late.
Eighteen-month-old mice, the early-aging model, got metformin in their water before and during a five-day chemical stress. Untreated stressed hearts pumped weakly and their power plants faltered. Metformin lowered the baseline strain and kept both pumping and power-plant function far stronger after the insult. The authors credit relief of that inner strain for the rescue.
Catalog record
| CREATOR | Qun Chen, Jeremy Thompson, Ying Hu, Edward J Lesnefsky |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |