Attenuated FTO induces necroptosis of alveolar epithelium via the m6A/CYP1B1/ROS/MLKL axis to promote the aggravation of pulmonary emphysema
Mindan Wu, Wenjing Wang, Zemin Chen, Yuanlan Yang, Jiawei Yan, Yachao Cui, Peiyu Huang, Feng Zhang, Wei Tu, Wensheng Chen, Ruiting Sun, Yumin Zhou, Leqing Zhu, Pixin Ran · 2026
Read Attenuated FTO induces necroptosis of alveolar epithelium via the m6A/CYP1B1/ROS/MLKL axis to promote the aggravation of pulmonary emphysema by Mindan Wu, Wenjing Wang, Zemin Chen, Yuanlan Yang, Jiawei Yan, Yachao Cui, Peiyu Huang, Feng Zhang, Wei Tu, Wensheng Chen, Ruiting Sun, Yumin Zhou, Leqing Zhu, Pixin Ran (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13251485.txt.
Description
Mindan Wu and co-authors trace a chain of molecular events that worsens emphysema, reporting in 2026. Emphysema, a core part of chronic obstructive pulmonary disease, destroys the tiny air sacs of the lung. The team focused on FTO, a protein that edits chemical marks on RNA and is concentrated in the lung cells that line those air sacs.
FTO levels were markedly lower in lung tissue from patients with the disease and from smoke-exposed mice, and lower levels tracked with worse lung function. Mice with reduced FTO developed emphysema on their own. The mechanism ran through a detox enzyme called CYP1B1: without FTO, its message lasted longer, reactive oxygen built up, and a form of inflammatory cell death called necroptosis switched on. Silencing that enzyme or giving an antioxidant eased the damage. The authors name FTO a possible target for protecting the lung.
Catalog record
| CREATOR | Mindan Wu, Wenjing Wang, Zemin Chen, Yuanlan Yang, Jiawei Yan, Yachao Cui, Peiyu Huang, Feng Zhang, Wei Tu, Wensheng Chen, Ruiting Sun, Yumin Zhou, Leqing Zhu, Pixin Ran |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |