Analysis of Viral Blips Through Week 192 of the DRIVE-FORWARD and DRIVE-AHEAD Phase 3 Studies of Doravirine-Based Regimens in Adults Living With Previously Untreated HIV-1
Jean-Michel Molina, Chloe Orkin, Roger Paredes, Zhi Jin Xu, Feng-Hsiu Su, Ernest Asante-Appiah, Rebeca M Plank, Rima Lahoulou · 2026
Read Analysis of Viral Blips Through Week 192 of the DRIVE-FORWARD and DRIVE-AHEAD Phase 3 Studies of Doravirine-Based Regimens in Adults Living With Previously Untreated HIV-1 by Jean-Michel Molina, Chloe Orkin, Roger Paredes, Zhi Jin Xu, Feng-Hsiu Su, Ernest Asante-Appiah, Rebeca M Plank, Rima Lahoulou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13251338.txt.
Description
Jean-Michel Molina and colleagues analyse brief virus rebounds in two large HIV trials in this 2026 paper. Blips are short spikes in virus levels between suppressed readings, and whether they warn of treatment failure matters for people on daily therapy.
The trials tested a doravirine-based regimen against standard rivals over 96 weeks, then extended treatment for 96 more. Blips hit about one in nine participants on doravirine, similar to rivals, and grew rarer later. Lower starting virus levels meant fewer blips. A fuller rebound of the virus was more common in people who had blips during the main trials, at about 14 percent versus six percent without blips.
Catalog record
| CREATOR | Jean-Michel Molina, Chloe Orkin, Roger Paredes, Zhi Jin Xu, Feng-Hsiu Su, Ernest Asante-Appiah, Rebeca M Plank, Rima Lahoulou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34031 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |