Untargeted serum metabolomic profiling in patients with generalized and ocular myasthenia gravis
Bin Wei, Haoyu Yuan, Jiawei He, Yuxiang Hu, Jing Li, Xiaorong Wu · 2026
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Description
Bin Wei and co-authors profile blood chemistry in patients with myasthenia gravis, in a 2026 study. Myasthenia gravis weakens muscles when the immune system attacks nerve signals. It comes in an ocular form, limited to the eyes, and a generalized form. The metabolic shifts behind those forms are poorly understood.
The team ran untargeted metabolomic profiling on fasting blood samples. Groups included generalized cases, ocular cases, and healthy controls. Advanced statistics separated the chemical patterns of each group. Distinct metabolite signatures marked the disease subtypes. Such signatures could aid diagnosis or track progression. They may also reveal pathways that new treatments could target. The study opens a metabolic window on a classic autoimmune disease.
Catalog record
| CREATOR | Bin Wei, Haoyu Yuan, Jiawei He, Yuxiang Hu, Jing Li, Xiaorong Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |