A motion-activated skeletal “Pacemaker” for systemic bone remodeling via oral piezoelectric microspheres
Wang Han, Jing Luo, Yingkun Xu, Xu He, Xinhe Li, Jindong Tan, Zijie Wang, Yi He, Peng Zou, Yi Peng, Xiaoyu Han, Dingqun Bai, Jieliang Shen · 2026
Read A motion-activated skeletal “Pacemaker” for systemic bone remodeling via oral piezoelectric microspheres by Wang Han, Jing Luo, Yingkun Xu, Xu He, Xinhe Li, Jindong Tan, Zijie Wang, Yi He, Peng Zou, Yi Peng, Xiaoyu Han, Dingqun Bai, Jieliang Shen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13251218.txt.
Description
Han and a large team build tiny spheres patients swallow that set the rhythm for bone, powered by daily motion. Their 2026 Bioactive Materials study targets osteoporosis, where bone loses its natural charge rhythms and steadily weakens. The spheres carry pressure-powered grains, coated to home to bone, inside soft gel shells.
Swallowed spheres passed the stomach, opened in the gut, and reached bone far more than controls in animal tests. Daily motion then squeezed the particles, making charge pulses in step with motion that raised bone's charge signaling within a day. Bone-eating cells quieted while bone building rose, and pairing with gentle workouts boosted both effects. The authors present the closed loop as a new, surgery-free way to restore bone balance.
Catalog record
| CREATOR | Wang Han, Jing Luo, Yingkun Xu, Xu He, Xinhe Li, Jindong Tan, Zijie Wang, Yi He, Peng Zou, Yi Peng, Xiaoyu Han, Dingqun Bai, Jieliang Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 99 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |