Gene set enrichment analysis of curated monogenic loci highlights key pathways and multisystem involvement in male infertility
Matthew Yang, Katreya Lovrenert, Nannan Thirumavalavan, Michael L. Eisenberg, Fredrick R. Schumacher, Chen-Han Wilfred Wu · 2026
Read Gene set enrichment analysis of curated monogenic loci highlights key pathways and multisystem involvement in male infertility by Matthew Yang, Katreya Lovrenert, Nannan Thirumavalavan, Michael L. Eisenberg, Fredrick R. Schumacher, Chen-Han Wilfred Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13251197.txt.
Description
Matthew Yang and colleagues mine gene lists for the roots of male infertility in this 2026 study. About one in ten men worldwide faces infertility, yet most cases never get a clear genetic answer, even as gene sequencing keeps finding single-gene causes.
The team gathered 596 candidate genes and focused on 178 with strong evidence. Group analysis showed these genes cluster in a few jobs: powering the tiny tails that move sperm, hormone making and sensing, and DNA repair. Many also switch on in organs beyond the testes, including hormone glands and the brain. The authors tie this to wider health links seen in infertile men and back whole-person care.
Catalog record
| CREATOR | Matthew Yang, Katreya Lovrenert, Nannan Thirumavalavan, Michael L. Eisenberg, Fredrick R. Schumacher, Chen-Han Wilfred Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26443 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |