Semi-automatic 3D-quantification of in-vivo synapse formation
Blaž Brence, Laura R. Wandelt, Sophie Walter, Stephan J. Sigrist, Astrid G. Petzoldt, Daniel Baum · 2026
Read Semi-automatic 3D-quantification of in-vivo synapse formation by Blaž Brence, Laura R. Wandelt, Sophie Walter, Stephan J. Sigrist, Astrid G. Petzoldt, Daniel Baum (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13251137.txt.
Description
Brence and co-authors automate the counting of newborn synapses in living fruit fly larvae. Their 2026 BMC Bioinformatics paper tackles a bottleneck: watching early synapse seeds form at the nerve-muscle junction took slow manual scoring of microscope images. The seeds are transient protein clusters that either stabilize into synapses or vanish within about an hour.
Their semi-automatic three-dimensional pipeline finds faint and crowded seed sites more sensitively than the older two-dimensional manual method. A proofreading step lets users correct the machine's calls while adding only a tenth more time. Overall the workflow cut analysis time by about seventy percent. The authors expect the tool to speed studies of how circuits wire themselves during development.
Catalog record
| CREATOR | Blaž Brence, Laura R. Wandelt, Sophie Walter, Stephan J. Sigrist, Astrid G. Petzoldt, Daniel Baum |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |