Transcriptional correlates of structure-function coupling plasticity in trigeminal neuralgia: unveiling the synaptic and metabolic associations
Jian Zhang, Xujing Nie, Shuyue Fu, Yinping Lu, Tiantian Liu, Zhilin Zhang, Jinglong Wu, Xuezhi Tong, Tianyi Yan · 2026
Read Transcriptional correlates of structure-function coupling plasticity in trigeminal neuralgia: unveiling the synaptic and metabolic associations by Jian Zhang, Xujing Nie, Shuyue Fu, Yinping Lu, Tiantian Liu, Zhilin Zhang, Jinglong Wu, Xuezhi Tong, Tianyi Yan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13251101.txt.
Description
Zhang and co-authors map how the brain's wiring and activity drift apart in trigeminal neuralgia, a severe facial pain disorder. Their 2026 Journal of Headache and Pain study scans eighty-seven patients and forty-two healthy controls, then rescans many patients after treatment. A graph-based measure captures how tightly brain structure and function stay coupled.
Patients showed looser coupling than controls, especially in movement and attention networks, and looser coupling tracked with worse pain and longer illness. After successful treatment, coupling returned to healthy levels, and bigger rebounds meant bigger pain relief. Gene maps linked the loosening to energy, ion balance, and inflammation genes, while recovery tied to synapse and natural opioid genes. The authors offer coupling as a possible marker for treatment planning.
Catalog record
| CREATOR | Jian Zhang, Xujing Nie, Shuyue Fu, Yinping Lu, Tiantian Liu, Zhilin Zhang, Jinglong Wu, Xuezhi Tong, Tianyi Yan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |