RBM39 upregulation promotes ostium re-obstruction after endoscopic endonasal dacryocystorhinostomy (En-DCR)
Jinjie Liu, Jinzhi Zhao, Xiaoyu Zhu, Xun Liu, Limin Zhu, Tingting Lin · 2026
Read RBM39 upregulation promotes ostium re-obstruction after endoscopic endonasal dacryocystorhinostomy (En-DCR) by Jinjie Liu, Jinzhi Zhao, Xiaoyu Zhu, Xun Liu, Limin Zhu, Tingting Lin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13251036.txt.
Description
Liu and co-authors search for why the new drainage opening after tear duct surgery sometimes scars shut again. Their 2026 BMC Molecular and Cell Biology study compares nasal tissue from thirty patients after endoscopic dacryocystorhinostomy, half with re-blockage and half with lasting success. The operation treats chronic tear sac inflammation and constant tearing.
Protein profiling singled out RBM39, a splicing-related protein, as markedly raised in re-blocked tissue, where it sat in vessel-lining cells. Forcing extra RBM39 in lab-grown vessel cells sped their growth, while silencing it slowed them. A cell-adhesion pathway looked like its likely route of action. The authors nominate RBM39 as a candidate target for keeping the surgical opening clear, pending causal proof.
Catalog record
| CREATOR | Jinjie Liu, Jinzhi Zhao, Xiaoyu Zhu, Xun Liu, Limin Zhu, Tingting Lin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |