Dysregulation of neurovascular unit in the retina after optic nerve injury
Qiong Wu, Hui Wang, HongJuan Liu, Luyin Zhang, Qiping Wei · 2026
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Description
Wu and co-authors examine how optic nerve injury unravels the retina's neurovascular unit in rats. Their 2026 BMC Ophthalmology study uses a measured pulling injury to the optic nerve to model traumatic optic neuropathy. The neurovascular unit is the team of nerve cells, support cells, and tiny vessels that keeps the retina working.
Two weeks after injury, electrical tests showed slower and weaker visual signals from the eye. Microscopy revealed damaged vessel basement membranes and loosened tight junctions inside the unit. Retinal ganglion cells thinned out while support cells overactivated, and key sealing proteins fell. The authors argue this unit breakdown helps drive vision loss and could supply markers and treatment targets for the human condition.
Catalog record
| CREATOR | Qiong Wu, Hui Wang, HongJuan Liu, Luyin Zhang, Qiping Wei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |