Overexpression of LINC00472 alleviates diabetic kidney disease progression via the miR-21-5p/STAT3 axis
Pengcheng Sun, Yutong Hu, Zihui Xu, Fei Xiong · 2026
Read Overexpression of LINC00472 alleviates diabetic kidney disease progression via the miR-21-5p/STAT3 axis by Pengcheng Sun, Yutong Hu, Zihui Xu, Fei Xiong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13250882.txt.
Description
Sun and co-authors examine a long non-coding RNA that seems to protect kidneys in diabetes. Their 2026 Renal Failure study compares samples from about one hundred diabetes patients and a similar number with diabetic kidney disease. The RNA, called LINC00472, also gets tested in kidney cells stressed by high sugar.
Levels of the RNA ran low in kidney disease patients and in sugar-stressed cells, and they tracked closely with kidney function measures. Adding extra copies calmed the cells, cutting scarring genes and inflammatory signals. A small partner RNA reversed those gains when boosted, and a signaling gene downstream completed the chain. The authors propose the RNA as both a diagnostic marker and a possible treatment lever for the disease.
Catalog record
| CREATOR | Pengcheng Sun, Yutong Hu, Zihui Xu, Fei Xiong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |