Fatty acids-based compounds as novel prophylaxis or treatment for oropharyngeal Neisseria gonorrhoeae: an in vitro study
Syed Ameer Hamza, Rita Paolini, Caroline Moore, Magnus Unemo, Tami Yap, Michael McCullough, Alyce Mayfosh, Thomas Rau, Stephen Kleid, Jane S Hocking, Fabian Ys Kong, Antonio Celentano · 2026
Read Fatty acids-based compounds as novel prophylaxis or treatment for oropharyngeal Neisseria gonorrhoeae: an in vitro study by Syed Ameer Hamza, Rita Paolini, Caroline Moore, Magnus Unemo, Tami Yap, Michael McCullough, Alyce Mayfosh, Thomas Rau, Stephen Kleid, Jane S Hocking, Fabian Ys Kong, Antonio Celentano (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13250877.txt.
Description
Hamza and a large team test fatty acid compounds as possible prevention or treatment for throat gonorrhea. Their 2026 Emerging Microbes and Infections study responds to rising drug resistance in Neisseria gonorrhoeae and few options for throat infections. Five throat and mouth cell lines were infected with two gonorrhea strains in the laboratory.
Two arginine-based fatty acids stood out, killing bacteria fast without harming any of the cell lines at tested doses. Applied after infection, they cleared more than nine tenths of bacteria within thirty minutes to two hours in most cell types. Applied before infection, one compound prevented most infections within half an hour. The authors propose topical use around sexual exposure as a future transmission reducer, pending human studies.
Catalog record
| CREATOR | Syed Ameer Hamza, Rita Paolini, Caroline Moore, Magnus Unemo, Tami Yap, Michael McCullough, Alyce Mayfosh, Thomas Rau, Stephen Kleid, Jane S Hocking, Fabian Ys Kong, Antonio Celentano |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |