TIM-1 promotes infection with mosquito cell-derived alphaviruses through virion-associated phospholipids
Ju Eun Yoo, Anja C. M. de Bruin, Hanna Reßin, Mindaugas Paužuolis, Lifeng Liu, Anja Moosmann, Miriam Becker, Lisa Lasswitz, Rüdiger Groß, Gisa Gerold · 2026
Read TIM-1 promotes infection with mosquito cell-derived alphaviruses through virion-associated phospholipids by Ju Eun Yoo, Anja C. M. de Bruin, Hanna Reßin, Mindaugas Paužuolis, Lifeng Liu, Anja Moosmann, Miriam Becker, Lisa Lasswitz, Rüdiger Groß, Gisa Gerold (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13250875.txt.
Description
Yoo and co-authors show that a human cell protein helps mosquito-grown alphaviruses infect mammalian cells. Their 2026 Emerging Microbes and Infections study focuses on TIM-1, a surface protein that grabs fatty molecules on virus coats. Viruses pick up their coats from host cells, and insect membranes differ from mammal membranes.
TIM-1 boosted infection by mosquito-grown chikungunya, O'nyong'nyong, and Sindbis viruses in cell tests. Its fat-binding pocket proved essential for the effect. Chemical profiling showed mosquito-grown virions carry more of two coat fats, and TIM-1 can engage both of them. The authors say the work widens understanding of TIM-1's targets and of how mosquito-borne viruses cross into human cells.
Catalog record
| CREATOR | Ju Eun Yoo, Anja C. M. de Bruin, Hanna Reßin, Mindaugas Paužuolis, Lifeng Liu, Anja Moosmann, Miriam Becker, Lisa Lasswitz, Rüdiger Groß, Gisa Gerold |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |