Efficacy of atopic dermatitis alleviation through transcutaneous auricular vagus nerve stimulation in 2,4-dinitrochlorobenzene (DNCB)-induced mouse model
Chan Mi Lee, Jae Hee Shin, Jae-Jun Song · 2026
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Description
Lee, Shin, and Song test ear-based nerve stimulation as a drug-free helper for eczema-like skin inflammation in mice. Their 2026 Annals of Medicine study uses a chemical called DNCB to trigger atopic dermatitis on mouse skin. Gentle electrical pulses on the ear stimulate the vagus nerve, a pathway known to calm immune responses.
Stimulated mice showed healthier skin structure and lower inflammatory markers than untreated dermatitis mice. Blocking acetylcholine receptors partly erased the benefit, pointing to cholinergic signaling, including one nicotine-type receptor, as part of the mechanism. Treatments ran a few minutes every two or three days for one or two weeks. The authors call the approach a promising add-on and ask for deeper mechanism and translation studies.
Catalog record
| CREATOR | Chan Mi Lee, Jae Hee Shin, Jae-Jun Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |