A retrospective cohort study comparing the effects on inflammatory response and clinical outcomes of vancomycin-PMMA versus vancomycin-sulfate calcium in chronic osteomyelitis
Shuman Han, Xirui Wu, Tianhao Wu · 2026
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Description
Han, Wu, and Wu compare two antibiotic-loaded materials for treating long-standing bone infections. Their 2026 Annals of Medicine study covers two hundred forty-four patients with chronic osteomyelitis treated between 2017 and 2024. One group received vancomycin in bone cement alone, and the other an added calcium sulfate carrier holding the same drug.
The combined material controlled infection in about seven of eight patients, versus roughly three of four with cement alone. Reoperations and overall complications both fell sharply in the combined group. Blood inflammation markers also dropped further, and quality-of-life scores for physical health and energy ran higher. The authors judge the combination a promising upgrade for this stubborn infection, worth wider clinical use.
Catalog record
| CREATOR | Shuman Han, Xirui Wu, Tianhao Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |