Revisiting the fluid challenge and stroke volume optimisation after induction of general anaesthesia
Terry O’Brien, Robert G Hahn · 2026
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Description
Terry O'Brien and Robert G. Hahn revisit a basic question of anesthesia care in their 2026 analysis of fluid challenges. Doctors give small fluid boluses after anesthesia starts to test whether the heart will pump more blood with extra volume. For that test to work, each bolus must expand blood volume by a similar, meaningful amount.
The authors re-examined trial data from 111 patients who each received three fluid challenges of crystalloid or colloid solution. Colloid raised stroke volume far more, with a median gain of 29.2 percent against only 2.5 percent for crystalloid fluid. Crystalloid also leaked into tissues faster, so later boluses expanded the blood less reliably. The authors warn that crystalloid challenges can wrongly label patients as fluid non-responders. They also note that anesthesia itself shifts fluid into the blood, which dulls the first reading.
Catalog record
| CREATOR | Terry O’Brien, Robert G Hahn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |