Cytoplasmic region of beta-dystroglycan is essential for postsynaptic maturation and neuromuscular function in mice
Jeffrey M. Hord, Rolf Turk, Hajime Kusano, Erik P. Rader, Sarah Burns, Zeita Gastel, Sally J. Prouty, Liping Yu, Steven J. Burden, Kevin P. Campbell · 2026
Read Cytoplasmic region of beta-dystroglycan is essential for postsynaptic maturation and neuromuscular function in mice by Jeffrey M. Hord, Rolf Turk, Hajime Kusano, Erik P. Rader, Sarah Burns, Zeita Gastel, Sally J. Prouty, Liping Yu, Steven J. Burden, Kevin P. Campbell (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13250547.txt.
Description
Jeffrey M. Hord and colleagues report 2026 mouse research on dystroglycan, a protein that anchors muscle fibers to their surroundings. The team focused on the part of the protein that sits inside the cell, at the junction where motor nerves meet muscle. They asked whether that inner section is required for the junction to mature and work.
Mice engineered to lack only the inner portion of beta-dystroglycan developed severe neuromuscular disease. Their nerve-muscle junctions failed to mature properly, and muscle function suffered as a result. The outer part of the protein, which binds the material around cells, was not enough on its own. The authors argue that the inside segment carries signals the synapse needs to stay stable. The finding helps explain how damage to this protein complex produces muscle disease.
Catalog record
| CREATOR | Jeffrey M. Hord, Rolf Turk, Hajime Kusano, Erik P. Rader, Sarah Burns, Zeita Gastel, Sally J. Prouty, Liping Yu, Steven J. Burden, Kevin P. Campbell |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |