Relationship of Genetic Variability (HIF‐1Α (rs11549465; P582S), TMPRSS6 (rs855791; V736A) and ABO (rs651007) and Iron Deficiency in Repeated Blood Donors in 2023: A Cross‐Sectional Study Towards Individualized Health Management
Mohammad Pouya Samiee, Azita Chegini, Majid Shahabi, Amir Teimourpour · 2026
Read Relationship of Genetic Variability (HIF‐1Α (rs11549465; P582S), TMPRSS6 (rs855791; V736A) and ABO (rs651007) and Iron Deficiency in Repeated Blood Donors in 2023: A Cross‐Sectional Study Towards Individualized Health Management by Mohammad Pouya Samiee, Azita Chegini, Majid Shahabi, Amir Teimourpour (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13250472.txt.
Description
Samiee and co-authors ask whether genes help explain why frequent blood donors run low on iron. Their 2026 Health Science Reports study recruited regular male donors at Iran's national blood service during 2023. Three gene variants tied to oxygen sensing, iron control, and blood group were tested against blood iron measures.
One variant, in the oxygen-sensing gene HIF-1 alpha, stood out: donors carrying one form kept clearly higher ferritin, the main iron storage marker. The other two variants showed no reliable link to iron status in this group. The authors suggest screening for this variant could personalize donor care, such as spacing donations or adding iron support. They call for larger, more varied studies that also weigh diet and environment.
Catalog record
| CREATOR | Mohammad Pouya Samiee, Azita Chegini, Majid Shahabi, Amir Teimourpour |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |