Polymorphism of pfmdr1 Gene Mutation Conferring Resistance to Artemisinin‐Based Combination Therapy in Plasmodium falciparum in Patients at Gulu Regional Referral Hospital in Northern Uganda
Florence Peace Amito, Harriet Angwech, Lonzy Ojok, Godfrey Wokorach, Stephen Ochaya, Quinto Ogwang, Robert Opiro, Richard Echodu, Satabdi Datta Choudhury · 2026
Read Polymorphism of pfmdr1 Gene Mutation Conferring Resistance to Artemisinin‐Based Combination Therapy in Plasmodium falciparum in Patients at Gulu Regional Referral Hospital in Northern Uganda by Florence Peace Amito, Harriet Angwech, Lonzy Ojok, Godfrey Wokorach, Stephen Ochaya, Quinto Ogwang, Robert Opiro, Richard Echodu, Satabdi Datta Choudhury (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13250382.txt.
Description
Amito and colleagues survey malaria parasites in northern Uganda for gene changes tied to drug resistance. Their 2026 Journal of Parasitology Research study enrolled fever patients at Gulu Regional Referral Hospital between April 2022 and January 2024. Parasite DNA was sequenced for resistance genes in the multidrug and kelch families.
Among three hundred fifty-three recruits, about three in five carried falciparum malaria, confirmed by rapid tests, microscopy, and genetic checks. Fever, chills, and headache dominated the reported symptoms. Resistance-linked variants were widespread, including changes in the kelch gene associated with artemisinin resistance in about one sixth of isolates. The authors urge ongoing monitoring of these markers to protect malaria control in the region and beyond.
Catalog record
| CREATOR | Florence Peace Amito, Harriet Angwech, Lonzy Ojok, Godfrey Wokorach, Stephen Ochaya, Quinto Ogwang, Robert Opiro, Richard Echodu, Satabdi Datta Choudhury |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |