Glucose-Responsive Dual-Enzyme Mimetic Nanoreactor Remodels Diabetic Periodontitis Microenvironment for Augmented Alveolar Bone Regeneration
Dai Wang, Jianzhao Chen, Junjie Wang, Haojie Chen, Wenqiang Li, Shan Shen · 2026
Read Glucose-Responsive Dual-Enzyme Mimetic Nanoreactor Remodels Diabetic Periodontitis Microenvironment for Augmented Alveolar Bone Regeneration by Dai Wang, Jianzhao Chen, Junjie Wang, Haojie Chen, Wenqiang Li, Shan Shen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13250248.txt.
Description
Wang and co-authors build a smart gel system to regrow jawbone lost to gum disease in diabetes. Their 2026 International Journal of Nanomedicine paper tackles a hostile repair site: high sugar, low oxygen, infection, and inflammation all block healing. The material packs manganese dioxide nanoflowers, tannic acid, and strontium inside a sugar-responsive hydrogel.
Once placed, an enzyme in the gel consumes local glucose, while the nanoflowers split peroxide and release oxygen. That sequence lowers sugar, eases oxygen shortage, mops up harmful reactive molecules, and fights bacteria. Tannic acid and strontium then release on schedule, steering immune cells toward a healing mode and speeding bone cell growth. In cell and animal tests, damaged bone repaired faster and with better quality.
Catalog record
| CREATOR | Dai Wang, Jianzhao Chen, Junjie Wang, Haojie Chen, Wenqiang Li, Shan Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |