Unveiling a ceRNA Network Involving IL-8 and TNF-α in Active Generalized Vitiligo by Multi-Omics Integration
Kang Ge, Yilu Zhao, Ruzhi Zhang · 2026
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Description
Ge, Zhao, and Zhang hunt for the molecular switches behind active generalized vitiligo, an autoimmune disease that destroys skin pigment cells. Their 2026 ImmunoTargets and Therapy paper combines protein and whole-transcriptome readings from blood samples. Three patients and three healthy volunteers supplied the discovery samples, with checks in a separate group.
The team found changed levels of many messenger, long non-coding, and circular RNAs, plus a small set of altered proteins. Network analysis highlighted ten hub genes tied to inflammation signals. Validation tests confirmed higher levels of two inflammatory cytokines, IL-8 and TNF-alpha, in patients. The authors propose a competing RNA network that may drive the inflammation and offer future treatment targets.
Catalog record
| CREATOR | Kang Ge, Yilu Zhao, Ruzhi Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |