Linear Association of Derivatives of Triglyceride-Glucose Index with Incident Lower Limb Joint Pain in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study [Letter]
JiaLe Li, ZiHao Yi, JiaWei Wu · 2026
Read Linear Association of Derivatives of Triglyceride-Glucose Index with Incident Lower Limb Joint Pain in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study [Letter] by JiaLe Li, ZiHao Yi, JiaWei Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13250245.txt.
Description
Li, Yi, and Wu write a 2026 letter to the editor of the Journal of Pain Research about a cohort study linking metabolic index scores to new leg joint pain. The study under discussion, by Xue and colleagues, used China's national retirement and health survey to test triglyceride-glucose index variants. The letter writers praise the longitudinal design before raising doubts.
Their first concern is added value: combined scores that included body size predicted pain, while the glucose index alone did not, suggesting fatness rather than metabolism drives the result. They ask for direct comparisons against simple body measures, with discrimination and calibration checks. Second, they flag the loss of more than seventeen hundred participants during follow-up, which in an aging cohort is unlikely to be random and could bias the findings.
Catalog record
| CREATOR | JiaLe Li, ZiHao Yi, JiaWei Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |