VSIG4 suppresses antitumor T cell immunity via the SLC3A2-dependent metabolic–ionic checkpoint
Guoling Huang, Ruirui He, Wei Wang, Heping Wang, Yangyang Li, Bo Zeng, Panyin Shu, Ting Pan, Ming Yi, Lingyun Feng, Zhihui Cui, Xi Li, Yanyun Du, Hong Jiang, Xue Xiao, Yuan Wang, Chenhui Wang · 2026
Read VSIG4 suppresses antitumor T cell immunity via the SLC3A2-dependent metabolic–ionic checkpoint by Guoling Huang, Ruirui He, Wei Wang, Heping Wang, Yangyang Li, Bo Zeng, Panyin Shu, Ting Pan, Ming Yi, Lingyun Feng, Zhihui Cui, Xi Li, Yanyun Du, Hong Jiang, Xue Xiao, Yuan Wang, Chenhui Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13250229.txt.
Description
Huang and co-authors uncover a new way tumors shut down killer T cells, centered on a protein called VSIG4. Their 2026 Journal for ImmunoTherapy of Cancer paper matters most for cold tumors like pancreatic cancer, where current immune drugs often fail. Earlier work tied VSIG4 to tumor growth, but not to how it controls T cells.
Blocking VSIG4 in mouse tumor models slowed growth and extended survival, especially in pancreatic cancer. Inside treated tumors, killer T cells became more numerous and more active. The team found that VSIG4 grabs a helper protein that moves amino acids, starving T cells of glutamine and scrambling their ion flows. Removing that block restored nutrients and ion balance, reviving the antitumor response.
Catalog record
| CREATOR | Guoling Huang, Ruirui He, Wei Wang, Heping Wang, Yangyang Li, Bo Zeng, Panyin Shu, Ting Pan, Ming Yi, Lingyun Feng, Zhihui Cui, Xi Li, Yanyun Du, Hong Jiang, Xue Xiao, Yuan Wang, Chenhui Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |