Propagation of α-synuclein pathology: models, mechanisms and future goals
Aryeh Zolin, Sarah A. Weber, Yan Xin Xie, Jacqueline Burré · 2026
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Description
Zolin, Weber, Xie, and Burré review how a rogue protein may crawl through the brain in Parkinson's disease, in a 2026 article. Alpha-synuclein, normally helpful, can misfold and clump, and those clumps seem to pass from cell to cell like prions, seeding damage along connected circuits. The authors weigh the evidence across four laboratory worlds: cultured cells, worms and flies, rodents, and monkeys.
Cell studies exposed possible release and uptake tricks but lack real circuitry. Rodents showed pathology marching along anatomical connections after a seed injection. Primates came closest to the human pattern, with long-distance spread and slow motor decline, at high practical cost. The authors admit the core mechanism of release and uptake is still unresolved and call for combined models.
Catalog record
| CREATOR | Aryeh Zolin, Sarah A. Weber, Yan Xin Xie, Jacqueline Burré |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |