A novel ZNF263-SMOX-ROS-TRIB3 signaling axis drives Wnt/β-catenin activation and metastatic progression in colorectal cancer
Longhe Sun, Youlei Zhang, Xianhu Zhang, Jiajie Zhou, Lili Ji, Ruiqi Li, Shuai Zhao, Yayan Fu, Jie Wang, Min Tang, Wei Wang, Chunhua Qian, Qiannan Sun, Daorong Wang · 2026
Read A novel ZNF263-SMOX-ROS-TRIB3 signaling axis drives Wnt/β-catenin activation and metastatic progression in colorectal cancer by Longhe Sun, Youlei Zhang, Xianhu Zhang, Jiajie Zhou, Lili Ji, Ruiqi Li, Shuai Zhao, Yayan Fu, Jie Wang, Min Tang, Wei Wang, Chunhua Qian, Qiannan Sun, Daorong Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13249687.txt.
Description
Sun and a large team traced a chain of molecular switches that helps colon cancer spread, in a 2026 Apoptosis study. The chain starts with a gene activator, ZNF263, switching on an enzyme called SMOX. Drawing on several cancer datasets plus cell and mouse experiments, the team tested each link by turning genes up or down.
SMOX ran high in tumors and marked worse survival. It raised reactive oxygen inside cells, which switched on TRIB3, a protein that in turn freed the Wnt growth pathway to drive invasion. Removing SMOX stalled cell growth and peritoneal spread in mice. The authors nominate the axis, especially SMOX and TRIB3, as drug targets.
Catalog record
| CREATOR | Longhe Sun, Youlei Zhang, Xianhu Zhang, Jiajie Zhou, Lili Ji, Ruiqi Li, Shuai Zhao, Yayan Fu, Jie Wang, Min Tang, Wei Wang, Chunhua Qian, Qiannan Sun, Daorong Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |