Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
Xiaoning Gao, Wuyan Guo, Peiyuan Liu, Mingyue Yuwen, Hongyu Ren, Shengtao Hu, Zixiang Liu, Ruyang Tan, Kairui Liu, Zhiru Yang, Junli Ba, Xue Bai, Shiti Shama, Cong Tang, Kai Miao, Haozhi Pei, Liren Liu, Cheng Zhu, Tao Wang, Bo Zhang, Jun Kang, Benoit Kornmann, Xiaoning Gao, Wuyan Guo, Peiyuan Liu, M · 2026
Read Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction by Xiaoning Gao, Wuyan Guo, Peiyuan Liu, Mingyue Yuwen, Hongyu Ren, Shengtao Hu, Zixiang Liu, Ruyang Tan, Kairui Liu, Zhiru Yang, Junli Ba, Xue Bai, Shiti Shama, Cong Tang, Kai Miao, Haozhi Pei, Liren Liu, Cheng Zhu, Tao Wang, Bo Zhang, Jun Kang, Benoit Kornmann, Xiaoning Gao, Wuyan Guo, Peiyuan Liu, M (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13249423.txt.
Description
Gao and a large Chinese team report that capsaicin, the heat in chili peppers, can shield the stomach from alcohol damage, in a 2026 eLife study. Alcohol burns the stomach lining partly through oxidative stress. Using binding assays and cell tests, the team showed capsaicin slips into the KEAP1 protein and loosens its grip on NRF2, the master switch for antioxidant defenses.
Freed NRF2 switched on protective genes in stomach cells, and the effect vanished in cells or mice lacking the relevant gene. Rats given capsaicin, including a nanoparticle version that dissolves better, suffered far less inflammation after alcohol dosing. The authors propose capsaicin as a gentler template for antioxidant drugs, since it does not bind permanently.
Catalog record
| CREATOR | Xiaoning Gao, Wuyan Guo, Peiyuan Liu, Mingyue Yuwen, Hongyu Ren, Shengtao Hu, Zixiang Liu, Ruyang Tan, Kairui Liu, Zhiru Yang, Junli Ba, Xue Bai, Shiti Shama, Cong Tang, Kai Miao, Haozhi Pei, Liren Liu, Cheng Zhu, Tao Wang, Bo Zhang, Jun Kang, Benoit Kornmann, Xiaoning Gao, Wuyan Guo, Peiyuan Liu, M |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 132 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |