Immunological consequences of senescence in physiology and pathology
Anastasija Zubova, Federico Pietrocola, Samir Morsli · 2026
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Description
Zubova, Pietrocola, and Morsli reviewed how aging cells interact with the immune system, in a 2026 paper. Cells that stop dividing under stress are called senescent, and they release a mix of signals that summon immune cells. Early in life that system clears damaged cells and aids repair, including during development and wound healing.
With age, immune patrols weaken, so senescent cells linger and their signals fuel constant low-grade inflammation. Immune cells themselves can turn senescent, deepening the cycle and aiding fibrosis and tumor growth. The authors survey therapies that clear such cells or refresh immunity, and they frame the two-way relationship as a target for age-related disease.
Catalog record
| CREATOR | Anastasija Zubova, Federico Pietrocola, Samir Morsli |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |