Integrative multi-omics profiling reveals distinct evolutionary and immunogenic features of brain oligometastasis in lung adenocarcinoma
Rongxin Liao, Qian Yu, Yusheng Huang, Hengqiu He, Mengmeng Song, Xuan Gao, Lu Shen, Yihao Tao, Lin Li, Gang Xiao, Rui Kong, Cancan Wang, Shunping Huang, Xiaoyue Zhang, Zaicheng Xu, Rongrong Zhou, Zhenzhou Yang, Yuan Peng · 2026
Read Integrative multi-omics profiling reveals distinct evolutionary and immunogenic features of brain oligometastasis in lung adenocarcinoma by Rongxin Liao, Qian Yu, Yusheng Huang, Hengqiu He, Mengmeng Song, Xuan Gao, Lu Shen, Yihao Tao, Lin Li, Gang Xiao, Rui Kong, Cancan Wang, Shunping Huang, Xiaoyue Zhang, Zaicheng Xu, Rongrong Zhou, Zhenzhou Yang, Yuan Peng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13248418.txt.
Description
Rongxin Liao and co-authors profile lung cancers that have spread to the brain in small numbers, using many layers of molecular data. Patients with few brain deposits can gain from strong local treatment, yet what makes this pattern distinct is unknown. Their 2026 study pairs twenty primary lung tumors with their brain deposits.
The pairs differed a lot from each other, the team found. Brain deposits were seeded by many cell clones at once and grew along parallel paths. Their immune surroundings were more suppressed than the lung tumors', with fewer active immune cells. One gene stood out as a possible driver: it was switched up in brain deposits, tied to worse outlook, and pushed brain spread in mice. The authors offer it as a target for study.
Catalog record
| CREATOR | Rongxin Liao, Qian Yu, Yusheng Huang, Hengqiu He, Mengmeng Song, Xuan Gao, Lu Shen, Yihao Tao, Lin Li, Gang Xiao, Rui Kong, Cancan Wang, Shunping Huang, Xiaoyue Zhang, Zaicheng Xu, Rongrong Zhou, Zhenzhou Yang, Yuan Peng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |